"The groundwork of all happiness is health." - Leigh Hunt

Brain implants to revive vision, similar to Neuralink's BlindSight, face a fundamental problem – more pixels don’t necessarily ensure higher vision.

Elon Musk announced recently that the subsequent Neuralink project might be a “blindsight” cortical implant to revive vision: “The resolution will be as low as Nintendo graphics at first, but may eventually exceed normal human vision.”

Unfortunately, it depends upon the claim. The misconception that neurons in the brain are like pixels on a screen.. It's not surprising that engineers often assume that “more pixels equals better vision.” After all, monitors and phone screens work the identical way.

In our newly published research, we created a A computational model of human vision To simulate what form of vision a really high-resolution cortical implant might provide. With a resolution of 45,000 pixels, the cat film is sharp and clear. A movie made using a simplified version of the model of 45,000 cortical electrodes, each stimulating a single neuron, still has a recognizable cat but most of the small print of the scene are lost.

The movie on the left is produced using 45,000 pixels. The one on the correct is produced using a simulation of a cortical prosthesis with 45,000 electrodes, each stimulating a single neuron.

The reason the film produced by the electrodes is so blurry is that neurons within the human visual cortex don't represent tiny dots or pixels. Instead, each neuron is exclusive receptive fieldThat is, the placement and pattern that a visible stimulus must be to ensure that the neuron to fireside. Electrically stimulating a neuron produces a blob whose appearance is decided by the neuron's receptive field. The smallest electrode—one which stimulates a single neuron—will produce a blob in regards to the length of your pinky-width arm.

The left image represents a single neuron that's electrically energetic. The right side represents what the patient can see. The size and shape of the blob depends upon the unique receptive field of the excitatory neuron.
Ioan Fine and Jeffrey Boynton/University of Washington

Consider what happens if you take a look at a star within the night sky. Each point in space is represented by several thousand neurons with overlapping receptive fields. A small point of sunshine, similar to a star, produces a posh pattern of firing across all these neurons.

The left side of the diagram shows the night sky with a single star.  The middle of the diagram shows the tiling of small empty circles that represent neurons.  In the center of this tiling is a cluster of circles filled with red, orange, and white to represent neuronal firing.  There are two insets in the right panel.  Each of these contains a differently oriented gray-scale blob, which represents the receptive field of two of these neurons.
A single star within the night sky triggers spikes in a whole lot of neurons, each with a definite receptive field.
Ioan Fine and Jeffrey Boynton/University of Washington

To create the visual experience of seeing a single star with cortical stimulation, you would want to breed a pattern of neural responses that resembles the pattern that's produced by natural vision.

The left diagram shows the tiling of small empty circles that represent neurons.  In the center of this tiling is a cluster of circles filled with red, orange, and white to represent neuronal firing.  A small, circular star is shown on a gray background to the right of the diagram.
Some scientists have suggested that by creating the correct stimulus patterns it might be possible to revive natural vision. But it will not be yet clear how this might be achieved.
Ioan Fine and Jeffrey Boynton/University of Washington

To do that, you'd obviously need 1000's of electrodes. But you'll also have to mimic the precise pattern of neuronal response, which requires knowing each neuron's receptive field. Our simulations show that knowing the placement of every neuron's receptive field in space will not be enough – if you happen to don't also know the direction and size of every receptive field, the star becomes a fuzzy mess.

The left diagram shows a tiling of small empty circles representing neurons, with a cluster of circles in the middle of this tiling filled with red, orange, and white.  A fuzzy white blob is shown on a gray background on the right side of the diagram.
If the orientation and size of the receptive field for every cell is unknown, the resulting image not looks like a star, despite using the identical electrode stimulation protocol.
Ioan Fine and Jeffrey Boynton/University of Washington

So, even a star—a single, shiny pixel—evokes a highly complex neural response within the visual cortex. Imagine a good more complex pattern of cortical stimulation required to accurately reproduce natural vision.

Some scientists have suggested that by stimulating the Correct combination of electrodesit would be possible Create a natural perspective. Unfortunately, nobody has yet proposed an affordable method for determining the receptive field of every individual neuron in a given blind patient. Without this information, there is no such thing as a approach to see the celebrities. Regardless of the variety of electrodes, vision from cortical implants will remain grainy and incomplete.

Vision restoration will not be simply an engineering problem. Predicting what form of vision a tool will provide requires knowing how Technology interfaces with the complexities of the human mind..

How we created our virtual patients

In our work as Computational Neuroscientistswe develop simulations that predict the perceptual experience of patients searching for to revive their vision.

We first built a model to make predictions. The perceptual experience of patients with retinal implants. To create a virtual patient to predict what cortical implant patients would see, we simulated the neurophysiological architecture of this a part of the brain. The first stage of visual processing. Our model takes under consideration how receptive fields increase in size from central to peripheral vision and the indisputable fact that each neuron has a novel receptive field.

Our model has successfully predicted Data describing the perceptual experience of participants in a large-scale study of cortical stimulation in humans. After confirming that our model could predict the present data, we used it to make predictions in regards to the quality of vision that future cortical implants might produce.

Models like ours are examples of this. Virtual prototypingThis includes using computer systems to enhance product design. These models can facilitate latest technology development and evaluate device performance. Our study suggests that they can also offer more realistic expectations about what form of vision bionic eyes can provide.

Do no harm first

In our nearly 20 years researching bionic eyes, we've seen the complexity of human brain defeat company after company. Patients pay the price. When these devices fail, they're left stuck with orphan technologies of their eyes or brains.

The Food and Drug Administration may mandate that vision recovery tech firms must prepare. Failure plans that minimize damage. For patients when technology stops working. Possibilities include requiring firms to implant neuroelectronic devices in patients to participate. Technology Escrow Agreements And carry insurance to make sure continuity. Medical care And Technology support If they go bankrupt.

If cortical implants can achieve anything near solving our simulations, it would still be an achievement value celebrating. Granular and incomplete vision might be life-changing for 1000's of people who find themselves currently affected by incurable blindness. But this can be a moment to be cautious quite than blindly optimistic.