"The groundwork of all happiness is health." - Leigh Hunt

Before The Last of Us, I used to be a part of a global team to chart the specter of a killer fungus. This is what we found

Posted by admin April 19, 2024

Fungal infections have gained attention due to the recognition of HBO. The last of us. The show depicts a fungal epidemic brought on by a real-life zombie ant fungus. It envisions the results of society's decline and a brutal approach to maintaining public health.

But in (real-life) laboratories, hospitals and public health units around the globe, researchers have been warning for years in regards to the rise of doubtless deadly fungal infections.

With few drugs to treat major fungal infections, and no vaccine on the horizon, the potential damage brought on by fungal infections has raised alarm at the very best levels of public health.

I used to be part of a big international team of researchers World Health Organization (WHO) to know which fungal pathogens we most must research and which pose the best public health threat. This has been revealed in his report.

The Last of Us reminds us just how deadly some cookie may be.

Before The Last of Us, many individuals thought “fungus” meant mushrooms or something loose in a compost pile. If they considered fungus when it comes to health, they thought. Player's feet or toenail infections – are familiar, but not scary.

However, the fungus could cause serious infections, especially in individuals with other health conditions. People living with cancer, HIV, or diabetes are especially vulnerable to those infections, but they may also goal individuals who have had major surgery, are within the intensive care unit, or who Have one other serious infection. This is because their immune system is weakened or compromised, leaving room for “opportunistic infections”.

We have seen this in India where black mold infections (mucormycosis) have complicated cases of COVID, leading to Thousands of deaths.

Becoming a threat and more

Before The Last of You, health officials were starting to take notice of great fungal infections.

In 2019, the US Centers for Disease Control Nominee Deadly yeast – that appeared out of nowhere. In 2009 – as “Immediate dangerDue to resistance to many (and sometimes all) known antifungal drugs.

is an 'immediate threat' since it is immune to most antifungal drugs.
Katrina Kahn/Shutterstock

A drug-resistant strain of Overuse of antifungal chemicals In agriculture, made a “watch” list.

New and increasingly drug-resistant pathogens akin to these are a public health challenge. Another is the increasing number of individuals susceptible to these infections.

Wealthier countries are providing more sophisticated health care than ever before, leading to more people affected by serious fungal infections. Chemotherapy, organ transplants, major surgery, extra healthy years living with diabetes all provide opportunities for the fungus to take hold.

Although risk aspects are different in low-income settings, the numbers tell the identical story—the speed of great fungal infections Globally are growing.

Then we worked with the WHO.

I used to be part of a big international team of researchers commissioned by the WHO to investigate the last ten years of research on fungal pathogens.

We conducted a world survey of fungal disease experts to know which pathogens are most in need of research and which pose the best threat to public health. WHO Published the results In a report released last yr.

They highlighted 4 principal priority pathogens:

  • which is immune to most antifungals and is an issue for vulnerable patients in hospitals.

  • , which primarily affects the lungs. Infections may be fatal, much more so when drug-resistant strains are involved.

  • which might cause invasive infections, normally in debilitated patients

  • , which might affect the brain, especially in immunocompromised people. This is particularly true in individuals with HIV, where it's a number one killer.

Aspergillus fumigatus
Mainly affects the lungs.
Katrina Kahn/Shutterstock

The WHO report calls for higher surveillance, a give attention to research and development, and enhancements in public health interventions, akin to higher prophylaxis (preventive treatment) or infection prevention strategies.

Viewers of The Last of Us will understand why these are so essential. We need surveillance so we all know where the threats are coming from, otherwise we cannot prepare.

We need more research and development to develop vaccines and recent treatments.

So far we have now didn't make any progress. Antifungal vaccine And there's no way we will develop and distribute it like we did for COVID.

Although some recent antifungals have turn into available, the range remains to be very limited, and a few varieties of fungi are immune to all available drugs.

Vaccines and medicines are difficult to develop because fungal cells are just like humans. Basic laboratory research is subsequently essential to discover ways wherein we will kill fungal cells without harming ourselves.

Without making a gift of any spoilers, it's secure to say that public health interventions abound in The Last of Us. Therefore, research on control and control of fungal pathogens can also be very essential to avoid such drastic and ineffective measures.

Are fungal infections possible?

The fungal frog plague, chytrid disease, has killed countless amphibians. Researchers say it is because The biggest loss of biodiversity from any disease ever recorded.

Is a fungal zombie apocalypse possible? Not for humans. In The Last of Us the fungus evolved over 1000's of years to contaminate a certain ant species and influence its behavior. There isn't any realistic possibility of this organism entering humans and controlling us.

However, if we don't work hard to know them higher we face very real threats from fungi – threats to our health, biodiversity, even food security. By acting now, we will prevent a possible public health crisis.