There are many difficulties in converting any biological research right into a drug that may treat patients. Due to the complexity involved, these difficulties, especially within the laboratory, apply to the interpretation of cell research into the successful treatment of heart failure, where the guts is unable to pump blood across the body properly.
The ultimate cure for heart failure is heart transplant – a difficult and expensive procedure. Pills are really useful for this condition, but they only delay death and will not be effective in changing the explanation for the disease.
Fifteen to twenty years ago, scientists enthusiastically began trying to find the usage of heart muscle cells, in order that the guts -wrenching heart could possibly be trapped within the hope that the guts was growing in the guts. Can create recent muscles. Although the outcomes of the animal test were positive, all of them failed in humans. Was included within the failures I and my colleagues held.
We will have the option to review animal studies and a few positive ends in small groups of patients. Happy with these results, we arranged a random control trial – the standard of gold for medical education in humans.
Our study was provided by the European Commission and made an important effort by a big group of researchers throughout Europe. The result was that therapy, through which bone marrow cells were injected into the guts muscle of patients with a heart attack, didn’t work.
So I used to be surprised to read recently that one Article in nature There was a warm welcome within the press on this topic. It was described in a distinct manner “Grand Breaking”For, for, for,. “Received” And a “Great advance”.
The authors of the article have reported the growing patch of heart muscle within the lab from advance cells after which apply the patches to the hearts of monkeys who were forced to suffer a heart attack, causing heart failure. There is
A girl who had a heart attack in 2016 also had this procedure. Three months later, he had a heart transplant, which allows researchers to investigate his heart.
Since it was only a matter of getting a human treatment, and this procedure was unsuccessful, because the guts was faraway from the patient, so the title of nature's article might be very wide in its scope: the guts Engineering for repair heart muscle allergies and humans.
It is noted that a senior creator of the article has announced that the corporate has shares that may make any success industrial. The dispute can have been announced, but it surely remains to be a possible dispute.
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Arrhythmia of the guts
The article doesn’t discuss the previous attempts to make use of heart muscle cells to treat heart failure in humans. Specifically, Surgeon Philip Mansha's fundamental work in Paris that reported in 2003 Lancer That he had a transparent success within the patient's myocardium (heart muscles) injected the muscle cells of the guts.
Then the outcomes appeared A study Where he repeated the identical procedure in a big group. The study was not successful. Mansha noted that some patients were affected by cardiac rhythmic abnormalities after this procedure.
There was numerous debate within the sector that junctions between transplant cells and the patient's own heart muscle cells could give rise to abnormal electrical activity, which could unimaginantly change the rhythm of the deadly heart.
Due to the history of cell therapy failure in human trials after positive tests in lab animals, the target reader should understand the implications of animal experiments with doubt.